Selecting Therapeutic Strategies Based on Efficacy and Death in Multicourse Clinical Trials
基于疗效与死亡结果选择多疗程临床试验治疗策略
Therapy of rapidly fatal diseases often requires multiple courses of treatment. In each course, the treatment may achieve the desired clinical goal (“response”), the patient may survive without response (“failure”), or the patient may die. When treatment fails in a given course, it is common medical practice to switch to a different treatment for the next course. Most statistical approaches to such settings simply ignore the multicourse structure. They characterize patient…