Placebo Response as a Latent Characteristic: Application to Analysis of Sequential Parallel Comparison Design Studies
将安慰剂反应视为潜在特征：序贯平行比较设计研究的分析
In clinical trials, placebo response can affect the inference about efficacy of the studied treatment. It is important to have a robust way to classify trial subjects with respect to their response to placebo. Simple, criterion-based classification may lead to classification error and bias the inference. The uncertainty about placebo response characteristic has to be factored into the treatment effect estimation. We propose a novel approach that views the placebo response as…