A Bayesian Population Model with Hierarchical Mixture Priors Applied to Blood Count Data
采用层次混合先验的贝叶斯总体模型及其血细胞计数应用
Population pharmacokinetic and pharmacodynamic studies require analyzing nonlinear growth curves fit to multiple measurements from study subjects. We propose a class of nonlinear population models with nonparametric second-stage priors for analyzing such data. The proposed models apply a flexible class of mixtures to implement the nonparametric second stage. The discussion is based on a pharmacodynamic study involving longitudinal data consisting of hematologic profiles…