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匹配病例对照研究中结合宽窄病例定义：家中枪支与自杀风险AI 解读

Does having firearms in the home increase suicide risk? To test this hypothesis, a matched case-control study can be performed, in which suicide case subjects are compared to living controls who are similar in observed covariates in terms of their retrospective exposure to firearms at home. In this application, cases can be defined using a broad case definition (suicide) or a narrow case definition (suicide occurred at home). The broad case definition offers a larger number…

含时变协变量纵向数据的边际回归分析：广义矩方法AI 解读

Summary We develop a new approach to using estimating equations to estimate marginal regression models for longitudinal data with time-dependent covariates. Our approach classifies time-dependent covariates into three types—types I, II and III. The type of covariate determines what estimating equations can be used involving the covariate. We use the generalized method of moments to make optimal use of the estimating equations that are made available by the covariates.…