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连续暴露与二元结局匹配观察研究的敏感性分析AI 解读

Summary Matching is one of the most widely used study designs for adjusting for measured confounders in observational studies. However, unmeasured confounding may exist and cannot be removed by matching. Therefore, a sensitivity analysis is typically needed to assess a causal conclusion’s sensitivity to unmeasured confounding. Sensitivity analysis frameworks for binary exposures have been well established for various matching designs and are commonly used in various studies.…

战争与工资AI 解读

An instrument manipulates a treatment that it does not entirely control, but the instrument affects the outcome only indirectly through its manipulation of the treatment. The idealized prototype is the randomized encouragement design, in which subjects are randomly assigned to receive either encouragement to accept the treatment or no such encouragement, but not all subjects comply by doing what they are encouraged to do, and the situation is such that only the treatment…

抑郁症治疗整群随机试验中的随机化推断AI 解读

In the Prospect Study, in 10 pairs of two primary-care practices, one practice was picked at random to receive a “depression care manager” to treat its depressed patients. Randomization inference, properly performed, reflects the assignment of practices, not patients, to treatment or control. Yet, pertinent data describe individual patients: depression outcomes, baseline covariates, compliance with treatment. The methods discussed use only (i) the random assignment of…

具有过度识别约束的工具变量回归敏感性分析AI 解读

Instrumental variables regression (IV regression) is a method for making causal inferences about the effect of a treatment based on an observational study in which there are unmeasured confounding variables. The method requires one or more valid instrumental variables (IVs); a valid IV is a variable that is associated with the treatment, is independent of unmeasured confounding variables, and has no direct effect on the outcome. Often there is uncertainty about the validity…