Does Finasteride Affect the Severity of Prostate Cancer? A Causal Sensitivity Analysis
非那雄胺是否影响前列腺癌严重程度:因果敏感性分析
In 2003 Thompson and colleagues reported that daily use of finasteride reduced the prevalence of prostate cancer by 25% compared to placebo. These results were based on the double-blind randomized Prostate Cancer Prevention Trial (PCPT) which followed 18,882 men with no prior or current indications of prostate cancer annually for seven years. Enthusiasm for the risk reduction afforded by the chemopreventative agent and adoption of its use in clinical practice, however, was…