Estimating disease attack rates in heterogeneous interacting populations, with applications to HIV vaccine trials
异质且相互作用人群中的疾病侵袭率估计及 HIV 疫苗试验应用
We describe models for infectious disease attack rates outside Aalen's multiplicative class and incorporating heterogeneity and interactions between subjects. Large-sample theory for the Nelson-Aalen estimator is developed, and its relevance examined in a simulation study. Planning for randomized, controlled clinical trials of prophylactic HIV vaccines partly motivated this work.