Maximum Rank Reproducibility: A Nonparametric Approach to Assessing Reproducibility in Replicate Experiments
最大秩可重复性:评估重复实验可重复性的非参数方法
The identification of reproducible signals from the results of replicate high-throughput experiments is an important part of modern biological research. Often little is known about the dependence structure and the marginal distribution of the data, motivating the development of a nonparametric approach to assess reproducibility. The procedure, which we call the maximum rank reproducibility (MaRR) procedure, uses a maximum rank statistic to parse reproducible signals from…