Nonparametric estimation of age-at-onset distributions from censored kin-cohort data
从删失亲属队列数据非参数估计发病年龄分布
We present a nonparametric estimator of genotype-specific age-at-onset distributions from kin-cohort data. Standard error calculations are derived and the methodology is illustrated through an analysis of the influence of mutations of the Parkin gene on Parkinson's disease. Semiparametric efficiency considerations are briefly discussed.