Estimating a Structured Covariance Matrix From Multilab Measurements in High-Throughput Biology
利用多实验室高通量生物测量估计结构化协方差矩阵
We consider the problem of quantifying the degree of coordination between transcription and translation, in yeast. Several studies have reported a surprising lack of coordination over the years, in organisms as different as yeast and human, using diverse technologies. However, a close look at this literature suggests that the lack of reported correlation may not reflect the biology of regulation. These reports do not control for between-study biases and structure in the…