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有限总体因果推断中的高斯预枢轴化AI 解读

Abstract In finite population causal inference exact randomization tests can be constructed for sharp null hypotheses, hypotheses which impute the missing potential outcomes. Oftentimes inference is instead desired for the weak null that the sample average of the treatment effects takes on a particular value while leaving the subject-specific treatment effects unspecified. Tests valid for sharp null hypotheses can be anti-conservative should only the weak null hold. We…

急诊普外科结局工具变量研究中的偏倚鼓励与异质性效应AI 解读

We investigate the efficacy of surgical versus nonsurgical management for two gastrointestinal conditions, colitis and diverticulitis, using observational data. We deploy an instrumental variable design with surgeons’ tendencies to operate as an instrument. Assuming instrument validity, we find that nonsurgical alternatives can reduce both hospital length of stay and the risk of complications, with estimated effects larger for septic patients than for nonseptic patients. The…

提高观察性研究中异常结局检验功效的自适应方法AI 解读

Abstract In many observational studies, the interest is in the effect of treatment on bad, aberrant outcomes rather than the average outcome. For such settings, the traditional approach is to define a dichotomous outcome indicating aberration from a continuous score and use the Mantel–Haenszel test with matched data. For example, studies of determinants of poor child growth use the World Health Organization’s definition of child stunting being height-for-age z-score ≤ − 2.…

配对观察性研究中样本平均处理效应的学生化敏感性分析AI 解读

A fundamental limitation of causal inference in observational studies is that perceived evidence for an effect might instead be explained by factors not accounted for in the primary analysis. Methods for assessing the sensitivity of a study’s conclusions to unmeasured confounding have been established under the assumption that the treatment effect is constant across all individuals. In the potential presence of unmeasured confounding, it has been argued that certain patterns…

缓解精细分层实验的分析局限AI 解读

Summary Although attractive from a theoretical perspective, finely stratified experiments such as paired designs suffer from certain analytical limitations that are not present in block-randomized experiments with multiple treated and control individuals in each block. In short, when using a weighted difference in means to estimate the sample average treatment effect, the traditional variance estimator in a paired experiment is conservative unless the pairwise average…

匹配观察研究中二元结局复合原假设的随机化推断与敏感性分析AI 解读

We present methods for conducting hypothesis testing and sensitivity analyses for composite null hypotheses in matched observational studies when outcomes are binary. Causal estimands discussed include the causal risk difference, causal risk ratio, and the effect ratio. We show that inference under the assumption of no unmeasured confounding can be performed by solving an integer linear program, while inference allowing for unmeasured confounding of a given strength requires…

重症脓毒症死亡率观察研究：可解释研究人群与随机化推断的离散优化AI 解读

Motivated by an observational study of the effect of hospital ward versus intensive care unit admission on severe sepsis mortality, we develop methods to address two common problems in observational studies: (1) when there is a lack of covariate overlap between the treated and control groups, how to define an interpretable study population wherein inference can be conducted without extrapolating with respect to important variables; and (2) how to use randomization inference…