Addressing Multiple Detection Limits with Semiparametric Cumulative Probability Models
用半参数累积概率模型处理多重检测限
Detection limits (DLs), where a variable cannot be measured outside of a certain range, are common in research. DLs may vary across study sites or over time. Most approaches to handling DLs in response variables implicitly make strong parametric assumptions on the distribution of data outside DLs. We propose a new approach to deal with multiple DLs based on a widely used ordinal regression model, the cumulative probability model (CPM). The CPM is a rank-based, semiparametric…