论文检索

控制错误发现率的局部关联搜索AI 解读

We introduce local conditional hypotheses that express how the relation between explanatory variables and outcomes changes across different contexts, described by covariates. By expanding upon the model-X knockoff filter, we show how to adaptively discover these local associations, all while controlling the false discovery rate. Our enhanced inferences can help explain sample heterogeneity and uncover interactions, making better use of the capabilities offered by modern…

捕捉信号：利用 knockoff e 值进行信号定位AI 解读

Abstract We consider problems where many, somewhat redundant, hypotheses are tested and we are interested in reporting the most precise rejections, with false discovery rate (FDR) control. This is the case, for example, when researchers are interested both in individual hypotheses as well as group hypotheses corresponding to intersections of sets of the original hypotheses, at several resolution levels. A concrete application is in genome-wide association studies, where,…

在保持错误发现率控制的同时筛选拒绝集合AI 解读

Scientific hypotheses in a variety of applications have domain-specific structures, such as the tree structure of the international classification of diseases (ICD), the directed acyclic graph structure of the gene ontology (GO), or the spatial structure in genome-wide association studies. In the context of multiple testing, the resulting relationships among hypotheses can create redundancies among rejections that hinder interpretability. This leads to the practice of…

利用自适应筛选程序检测多个可重复信号AI 解读

Replicability is a fundamental quality of scientific discoveries: we are interested in those signals that are detectable in different laboratories, different populations, across time etc. Unlike meta-analysis which accounts for experimental variability but does not guarantee replicability, testing a partial conjunction (PC) null aims specifically to identify the signals that are discovered in multiple studies. In many contemporary applications, for example, comparing…