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We describe methods for the construction of a confidence interval for median survival time based on right-censored data. These methods are extended to the construction of repeated confidence intervals for the median, based on accumulating data; here, the overall probability that all intervals contain the true median is guaranteed at a fixed level. The use of repeated confidence intervals for median survival time in post-marketing surveillance is discussed.

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SUMMARY Assuming a smooth trend plus independent error model for the environmental effects in the yields of a field plot experiment, least squares smoothing methods are developed to estimate both the treatment effects and the unknown trend. Treatment estimates are closely related to those resulting from a generalized least squares analysis in which the covariance structure for the environmental effects has a particular form. However, the main emphases are on the accuracy of…