Two-stage testing procedures with independent filtering for genome-wide gene-environment interaction
基因组范围基因—环境交互的独立筛选两阶段检验
Several two-stage multiple testing procedures have been proposed to detect gene-environment interaction in genome-wide association studies. In this article, we elucidate general conditions that are required for validity and power of these procedures, and we propose extensions of two-stage procedures using the case-only estimator of gene-treatment interaction in randomized clinical trials. We develop a unified estimating equation approach to proving asymptotic independence…