Ultra-High Dimensional Quantile Regression for Longitudinal Data: An Application to Blood Pressure Analysis
纵向数据的超高维分位数回归:血压分析应用
Despite major advances in research and treatment, identifying important genotype risk factors for high blood pressure remains challenging. Traditional genome-wide association studies (GWAS) focus on one single nucleotide polymorphism (SNP) at a time. We aim to select among over half a million SNPs along with time-varying phenotype variables via simultaneous modeling and variable selection, focusing on the most dangerous blood pressure levels at high quantiles. Taking…