Multiple Test Procedures for Identifying the Minimum Effective and Maximum Safe Doses of a Drug
识别药物最低有效剂量与最高安全剂量的多重检验
We address the problem of determining the therapeutic window of a drug by finding its minimum effective and maximum safe doses (MINED and MAXSD). The MINED is the lowest dose that exceeds the mean efficacy of the zero dose by a specified threshold, and the MAXSD is the highest dose that does not exceed the mean toxicity of the zero dose by a specified threshold. Step-down multiple test procedures are proposed to identify the MINED and MAXSD assuming a bivariate normal model.…