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含终止事件纵向数据的二元时变系数模型核估计AI 解读

We propose a nonparametric bivariate time-varying coefficient model for longitudinal measurements with the occurrence of a terminal event that is subject to right censoring. The time-varying coefficients capture the longitudinal trajectories of covariate effects along with both the followup time and the residual lifetime. The proposed model extends the parametric conditional approach given terminal event time in recent literature, and thus avoids potential model…

时间依赖观测下高维协方差与精度矩阵的估计AI 解读

We consider the estimation of large covariance and precision matrices from high-dimensional sub-Gaussian or heavier-tailed observations with slowly decaying temporal dependence. The temporal dependence is allowed to be long-range so with longer memory than those considered in the current literature. We show that several commonly used methods for independent observations can be applied to the temporally dependent data. In particular, the rates of convergence are obtained for…

伴随终末事件的纵向数据条件建模AI 解读

We consider a random effects model for longitudinal data with the occurrence of an informative terminal event that is subject to right censoring. Existing methods for analyzing such data include the joint modeling approach using latent frailty and the marginal estimating equation approach using inverse probability weighting; in both cases the effect of the terminal event on the response variable is not explicit and thus not easily interpreted. In contrast, we treat the…

纵向数据折线回归模型参数的快速估计AI 解读

Estimation of change-point locations in the broken-stick model has significant applications in modeling important biological phenomena. In this article we present a computationally economical likelihood-based approach for estimating change-point(s) efficiently in both cross-sectional and longitudinal settings. Our method, based on local smoothing in a shrinking neighborhood of each change-point, is shown via simulations to be computationally more viable than existing methods…

含检测限协变量的回归半参数方法AI 解读

We consider generalized linear regression with a covariate left-censored at a lower detection limit. Complete-case analysis, where observations with values below the limit are eliminated, yields valid estimates for regression coefficients but loses efficiency, ad hoc substitution methods are biased, and parametric maximum likelihood estimation relies on parametric models for the unobservable tail probability distribution and may suffer from model misspecification. To obtain…

半参数模型中捆绑参数的筛 M 定理及其删失线性模型有效估计应用AI 解读

In many semiparametric models that are parameterized by two types of parameters - a Euclidean parameter of interest and an infinite-dimensional nuisance parameter, the two parameters are bundled together, i.e., the nuisance parameter is an unknown function that contains the parameter of interest as part of its argument. For example, in a linear regression model for censored survival data, the unspecified error distribution function involves the regression coefficients.…

含缺失数据的半参数加速失效时间模型渐近理论AI 解读

We consider a class of doubly weighted rank-based estimating methods for the transformation (or accelerated failure time) model with missing data as arise, for example, in case-cohort studies. The weights considered may not be predictable as required in a martingale stochastic process formulation. We treat the general problem as a semiparametric estimating equation problem and provide proofs of asymptotic properties for the weighted estimators, with either true weights or…

病例队列研究中的删失线性回归AI 解读

Right-censored data from a classical case-cohort design and a stratified case-cohort design are considered. In the classical case-cohort design the subcohort is obtained as a simple random sample of the entire cohort, whereas in the stratified design this subcohort is elected by independent Bernoulli sampling with arbitrary selection probabilities. For each design and under a linear regression model, methods for estimating the regression parameters are proposed and analysed.…

标志事件年龄与绝经年龄关联的分段常数交叉比估计AI 解读

A question of significant interest in female reproductive aging is to identify bleeding criteria for menopausal transition. Although various bleeding criteria, or markers, have been proposed for menopausal transition, their validity has not been adequately examined. The Tremin Trust data were collected from a long-term cohort study that followed a group of women throughout their whole reproductive life. Such data provide a unique opportunity for evaluating the utility of a…

缺失数据下 Cox 回归模型的信息界AI 解读

We derive information bounds for the regression parameters in Cox models when data are missing at random. These calculations are of interest for understanding the behavior of efficient estimation in case-cohort designs, a type of two-phase design often used in cohort studies. The derivations make use of key lemmas appearing in Robins, Rotnitzky and Zhao [J. Amer. Statist. Assoc. 89 (1994) 846–866] and Robins, Hsieh and Newey [J. Roy. Statist. Soc. Ser. B 57 (1995) 409–424],…