Importance Sampling for Estimating p Values in Linkage Analysis
用于连锁分析 p 值估计的重要性抽样
Importance sampling methods are proposed for estimating the probability that the maximum of a random process exceeds a high threshold, with particular attention to assessing genome-wide significance levels in linkage analysis. The proposed algorithm is applied to computing the conditional significance level, given observed phenotypes, of scan statistics to map quantitative traits in experimental populations and in extended pedigrees of moderate size with partially…