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免疫治疗的贝叶斯 I/II 期临床试验设计AI 解读

Immunotherapy is an innovative treatment approach that stimulates a patient's immune system to fight cancer. It demonstrates characteristics distinct from conventional chemotherapy and stands to revolutionize cancer treatment. We propose a Bayesian phase I/II dosefinding design that incorporates the unique features of immunotherapy by simultaneously considering three outcomes: immune response, toxicity and efficacy. The objective is to identify the biologically optimal dose,…

精准医疗中基于生物标志物的贝叶斯Ⅰ/Ⅱ期剂量探索AI 解读

Beibei Guoa* & Ying Yuanba Department of Experimental Statistics, Louisiana State University, Baton Rouge, LAb Department of Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TXCONTACT Beibei Guo beibeiguo@lsu.edu Department of Experimental Statistics, Louisiana State University, Baton Rouge, LA 70803Color versions of one or more of the figures in the article can be found online at www.tandfonline.com/r/JASA.Supplementary materials for this article are…