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Multiscale scanning with nuisance parameters

含干扰参数的多尺度扫描

Abstract We develop a multiscale scanning method to find anomalies in a d-dimensional random field in the presence of nuisance parameters. This covers the common situation that either the baseline-level or additional parameters such as the variance are unknown and have to be estimated from the data. We argue that state of the art approaches to determine asymptotically correct critical values for multiscale scanning statistics will in general fail when such parameters are…

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Distribution of Distances based Object Matching: Asymptotic Inference

基于距离分布的对象匹配:渐近推断

In this article, we aim to provide a statistical theory for object matching based on a lower bound of the Gromov-Wasserstein distance related to the distribution of (pairwise) distances of the considered objects. To this end, we model general objects as metric measure spaces. Based on this, we propose a simple and efficiently computable asymptotic statistical test for pose invariant object discrimination. This is based on a (β-trimmed) empirical version of the…

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Multiscale Quantile Segmentation

多尺度分位数分段

We introduce a new methodology for analyzing serial data by quantile regression assuming that the underlying quantile function consists of constant segments. The procedure does not rely on any distributional assumption besides serial independence. It is based on a multiscale statistic, which allows to control the (finite sample) probability for selecting the correct number of segments S at a given error level, which serves as a tuning parameter. For a proper choice of this…

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Posterior analysis of n in the binomial (n,p) problem with both parameters unknown—with applications to quantitative nanoscopy

二项模型中参数均未知时总体规模的后验分析及定量纳米成像应用

Estimation of the population size n from k i.i.d. binomial observations with unknown success probability p is relevant to a multitude of applications and has a long history. Without additional prior information this is a notoriously difficult task when p becomes small, and the Bayesian approach becomes particularly useful. For a large class of priors, we establish posterior contraction and a Bernstein-von Mises type theorem in a setting where p→0 and n→∞ as k→∞. Furthermore,…

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What is resolution? A statistical minimax testing perspective on superresolution microscopy

何谓分辨率:超分辨显微成像的统计极小极大检验视角

As a general rule of thumb the resolution of a light microscope (i.e., the ability to discern objects) is predominantly described by the full width at half maximum (FWHM) of its point spread function (psf)—the diameter of the blurring density at half of its maximum. Classical wave optics suggests a linear relationship between FWHM and resolution also manifested in the well-known Abbe and Rayleigh criteria, dating back to the end of the 19th century. However, during the last…

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Frame-constrained total variation regularization for white noise regression

白噪声回归中的框架约束总变差正则化

Despite the popularity and practical success of total variation (TV) regularization for function estimation, surprisingly little is known about its theoretical performance in a statistical setting. While TV regularization has been known for quite some time to be minimax optimal for denoising one-dimensional signals, for higher dimensions this remains elusive until today. In this paper, we consider frame-constrained TV estimators including many well-known (overcomplete)…

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The essential histogram

本质直方图

Summary The histogram is widely used as a simple, exploratory way of displaying data, but it is usually not clear how to choose the number and size of the bins. We construct a confidence set of distribution functions that optimally deal with the two main tasks of the histogram: estimating probabilities and detecting features such as increases and modes in the distribution. We define the essential histogram as the histogram in the confidence set with the fewest bins. Thus the…

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Multidimensional multiscale scanning in exponential families: Limit theory and statistical consequences

指数族中的多维多尺度扫描:极限理论与统计结论

We consider the problem of finding anomalies in a $d$-dimensional field of independent random variables $\{Y_{i}\}_{i\in \{1,\ldots,n\}^{d}}$, each distributed according to a one-dimensional natural exponential family $\mathcal{F}=\{F_{\theta }\}_{\theta \in \Theta }$. Given some baseline parameter $\theta _{0}\in \Theta $, the field is scanned using local likelihood ratio tests to detect from a (large) given system of regions $\mathcal{R}$ those regions $R\subset \{1,\ldots,n\}^{d}$…

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Multiscale scanning in inverse problems

逆问题中的多尺度扫描

In this paper, we propose a multiscale scanning method to determine active components of a quantity $f$ w.r.t. a dictionary $\mathcal{U}$ from observations $Y$ in an inverse regression model $Y=Tf+\xi$ with linear operator $T$ and general random error $\xi$. To this end, we provide uniform confidence statements for the coefficients $\langle\varphi,f\rangle$, $\varphi\in\mathcal{U}$, under the assumption that $(T^{*})^{-1}(\mathcal{U})$ is of wavelet-type. Based on this, we…

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Multiscale blind source separation

多尺度盲源分离

We provide a new methodology for statistical recovery of single linear mixtures of piecewise constant signals (sources) with unknown mixing weights and change points in a multiscale fashion. We show exact recovery within an $\varepsilon$-neighborhood of the mixture when the sources take only values in a known finite alphabet. Based on this we provide the SLAM (Separates Linear Alphabet Mixtures) estimators for the mixing weights and sources. For Gaussian error, we obtain…

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Inference for Empirical Wasserstein Distances on Finite Spaces

有限空间上经验 Wasserstein 距离的统计推断

Summary The Wasserstein distance is an attractive tool for data analysis but statistical inference is hindered by the lack of distributional limits. To overcome this obstacle, for probability measures supported on finitely many points, we derive the asymptotic distribution of empirical Wasserstein distances as the optimal value of a linear programme with random objective function. This facilitates statistical inference (e.g. confidence intervals for sample-based Wasserstein…

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Heterogeneous Change Point Inference

异质变点推断

Summary We propose, a heterogeneous simultaneous multiscale change point estimator called ‘H-SMUCE’ for the detection of multiple change points of the signal in a heterogeneous Gaussian regression model. A piecewise constant function is estimated by minimizing the number of change points over the acceptance region of a multiscale test which locally adapts to changes in the variance. The multiscale test is a combination of local likelihood ratio tests which are properly…

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Drift Estimation in Sparse Sequential Dynamic Imaging, With Application to Nanoscale Fluorescence Microscopy

稀疏序贯动态成像中的漂移估计及纳米荧光显微应用

Summary A major challenge in many modern superresolution fluorescence microscopy techniques at the nanoscale lies in the correct alignment of long sequences of sparse but spatially and temporally highly resolved images. This is caused by the temporal drift of the protein structure, e.g. due to temporal thermal inhomogeneity of the object of interest or its supporting area during the observation process. We develop a simple semiparametric model for drift correction in…

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Partial least squares for dependent data

相依数据的偏最小二乘法

We consider the partial least squares algorithm for dependent data and study the consequences of ignoring the dependence both theoretically and numerically. Ignoring nonstationary dependence structures can lead to inconsistent estimation, but a simple modification yields consistent estimation. A protein dynamics example illustrates the superior predictive power of the proposed method.

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Multiscale Change Point Inference

多尺度变点推断

Summary We introduce a new estimator, the simultaneous multiscale change point estimator SMUCE, for the change point problem in exponential family regression. An unknown step function is estimated by minimizing the number of change points over the acceptance region of a multiscale test at a level α. The probability of overestimating the true number of change points K is controlled by the asymptotic null distribution of the multiscale test statistic. Further, we derive…

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Multiscale methods for shape constraints in deconvolution: Confidence statements for qualitative features

反卷积中的形状约束多尺度方法:定性特征的置信陈述

We derive multiscale statistics for deconvolution in order to detect qualitative features of the unknown density. An important example covered within this framework is to test for local monotonicity on all scales simultaneously. We investigate the moderately ill-posed setting, where the Fourier transform of the error density in the deconvolution model is of polynomial decay. For multiscale testing, we consider a calibration, motivated by the modulus of continuity of Brownian…

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Möbius deconvolution on the hyperbolic plane with application to impedance density estimation

双曲平面上的莫比乌斯反卷积及阻抗密度估计

In this paper we consider a novel statistical inverse problem on the Poincaré, or Lobachevsky, upper (complex) half plane. Here the Riemannian structure is hyperbolic and a transitive group action comes from the space of 2 × 2 real matrices of determinant one via Möbius transformations. Our approach is based on a deconvolution technique which relies on the Helgason–Fourier calculus adapted to this hyperbolic space. This gives a minimax nonparametric density estimator of a…

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Consistencies and rates of convergence of jump-penalized least squares estimators

跳跃惩罚最小二乘估计的一致性与收敛速度

We study the asymptotics for jump-penalized least squares regression aiming at approximating a regression function by piecewise constant functions. Besides conventional consistency and convergence rates of the estimates in L2([0, 1)) our results cover other metrics like Skorokhod metric on the space of càdlàg functions and uniform metrics on C([0, 1]). We will show that these estimators are in an adaptive sense rate optimal over certain classes of “approximation spaces.”…

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Testing for Lack of Fit in Inverse Regression—with Applications to Biophotonic Imaging

逆回归中的失拟检验及其生物光子成像应用

Summary We propose two test statistics for use in inverse regression problems Y = Kθ+ε, where K is a given linear operator which cannot be continuously inverted. Thus, only noisy, indirect observations Y for the function θ are available. Both test statistics have a counterpart in classical hypothesis testing, where they are called the order selection test and the data-driven Neyman smooth test. We also introduce two model selection criteria which extend the classical Akaike…

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Non-Parametric Confidence Bands in Deconvolution Density Estimation

反卷积密度估计中的非参数置信带

Summary Uniform confidence bands for densities f via non-parametric kernel estimates were first constructed by Bickel and Rosenblatt. In this paper this is extended to confidence bands in the deconvolution problem g=f*ψ for an ordinary smooth error density ψ. Under certain regularity conditions, we obtain asymptotic uniform confidence bands based on the asymptotic distribution of the maximal deviation (L∞-distance) between a deconvolution kernel estimator f^ and f. Further…

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On Difference-Based Variance Estimation in Nonparametric Regression When the Covariate is High Dimensional

高维协变量下非参数回归的差分型方差估计

Summary We consider the problem of estimating the noise variance in homoscedastic nonparametric regression models. For low dimensional covariates t ∈ ℝd, d=1, 2, difference-based estimators have been investigated in a series of papers. For a given length of such an estimator, difference schemes which minimize the asymptotic mean-squared error can be computed for d=1 and d=2. However, from numerical studies it is known that for finite sample sizes the performance of these…

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Nonparametric comparison of several regression functions: exact and asymptotic theory

多个回归函数的非参数比较:精确与渐近理论

A new test is proposed for the comparison of two regression curves $f$ and $g$. We prove an asymptotic normal law under fixed alternatives which can be applied for power calculations, for constructing confidence regions and for testing precise hypotheses of a weighted $L_2$ distance between $f$ and $g$ . In particular, the problem of nonequal sample sizes is treated, which is related to a peculiar formula of the area between two step functions. These results are extended in…

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Estimating the Variance In Nonparametric Regression—What is a Reasonable Choice?

非参数回归中的方差估计:怎样选择才合理?

Summary The exact mean-squared error (MSE) of estimators of the variance in nonparametric regression based on quadratic forms is investigated. In particular, two classes of estimators are compared: Hall, Kay and Titterington's optimal difference-based estimators and a class of ordinary difference-based estimators which generalize methods proposed by Rice and Gasser, Sroka and Jennen-Steinmetz. For small sample sizes the MSE of the first estimator is essentially increased by…

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Testing Heteroscedasticity In Nonparametric Regression

非参数回归中的异方差检验

Summary The importance of being able to detect heteroscedasticity in regression is widely recognized because efficient inference for the regression function requires that heteroscedasticity is taken into account. In this paper a simple consistent test for heteroscedasticity is proposed in a nonparametric regression set-up. The test is based on an estimator for the best L 2-approximation of the variance function by a constant. Under mild assumptions asymptotic normality of…

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