Randomization Inference With Imperfect Compliance in the ACE-Inhibitor After Anthracycline Randomized Trial
蒽环类药物治疗后 ACE 抑制剂试验中不完全依从下的随机化推断
Anthracyclines are quite effective at curing certain cancers of childhood, but they may damage the heart. The ACE-Inhibitor After Anthracycline (AAA) study compared enalapril to placebo in a randomized trial in an effort to determine whether treatment with enalapril would preserve or improve cardiac function among children previously treated with anthracylines. As is true in many clinical trials, patient compliance with the study protocol was imperfect; some children took…