On the bias in estimating genetic length and other quantities in simplex constrained models
单纯形约束模型中遗传距离及其他量的估计偏差
The genetic distance between two loci on a chromosome is defined as the mean number of crossovers between the loci. The parameters of the crossover distribution are constrained by the parameters of the distribution of chiasmata. Ott (1996) derived the maximum likelihood estimator (MLE) of the parameters of the crossover distribution and the MLE of the mean. We demonstrate that the MLE of the mean is pointwise less than or equal to the empirical mean number of crossovers. It…