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基于潜在因子模型的个体化动态中介分析AI 解读

Mediation analysis plays a crucial role in causal inference as it can investigate the pathways through which treatment influences outcome. Most existing mediation analysis assumes that mediation effects are static and homogeneous within populations. However, mediation effects usually change over time and exhibit significant heterogeneity among individuals in many real-world applications. Additionally, the mediation mechanism can be complicated and involves non-sparse, making…

整合局部与全局信息的模型无关图神经网络AI 解读

Graph Neural Networks (GNNs) have achieved promising performance in a variety of graph-focused tasks. Despite their success, however, existing GNNs suffer from two significant limitations: a lack of interpretability in their results due to their black-box nature, and an inability to learn representations of varying orders. To tackle these issues, we propose a novel Model-agnostic Graph Neural Network (MaGNet) framework, which is able to effectively integrate information of…

预算约束下组合治疗的最优个体化治疗规则AI 解读

Abstract The individualized treatment rule (ITR), which recommends an optimal treatment based on individual characteristics, has drawn considerable interest from many areas such as precision medicine, personalized education, and personalized marketing. Existing ITR estimation methods mainly adopt 1 of 2 or more treatments. However, a combination of multiple treatments could be more powerful in various areas. In this paper, we propose a novel double encoder model (DEM) to…

利用潜在多中介路径消除因果推断中的混杂AI 解读

Causal effect estimation from observational data is one of the essential problems in causal inference. However, most estimation methods rely on the strong assumption that all confounders are observed, which is impractical and untestable in the real world. We develop a mediation analysis framework inferring the latent confounder for debiasing both direct and indirect causal effects. Specifically, we introduce generalized structural equation modeling that incorporates…

通过 pT-Learning 估计无限期最优动态治疗方案AI 解读

Recent advances in mobile health (mHealth) technology provide an effective way to monitor individuals’ health statuses and deliver just-in-time personalized interventions. However, the practical use of mHealth technology raises unique challenges to existing methodologies on learning an optimal dynamic treatment regime. Many mHealth applications involve decision-making with large numbers of intervention options and under an infinite time horizon setting where the number of…

面向多层次连边预测的高阶联合嵌入AI 解读

Link prediction infers potential links from observed networks, and is one of the essential problems in network analyses. In contrast to traditional graph representation modeling which only predicts two-way pairwise relations, we propose a novel tensor-based joint network embedding approach on simultaneously encoding pairwise links and hyperlinks onto a latent space, which captures the dependency between pairwise and multi-way links in inferring potential unobserved…

利用多类别角度学习估计删失数据下的最优动态治疗方案AI 解读

An optimal dynamic treatment regime (DTR) consists of a sequence of decision rules in maximizing long-term benefits, which is applicable for chronic diseases such as HIV infection or cancer. In this article, we develop a novel angle-based approach to search the optimal DTR under a multicategory treatment framework for survival data. The proposed method targets to maximize the conditional survival function of patients following a DTR. In contrast to most existing approaches…

连接存在依赖时的社区检测AI 解读

In network analysis, within-community members are more likely to be connected than between-community members, which is reflected in that the edges within a community are intercorrelated. However, existing probabilistic models for community detection such as the stochastic block model (SBM) are not designed to capture the dependence among edges. In this paper, we propose a new community detection approach to incorporate intra-community dependence of connectivities through the…

个体化多方向变量选择AI 解读

In this article, we propose a heterogeneous modeling framework which achieves individual-wise feature selection and heterogeneous covariates’ effects subgrouping simultaneously. In contrast to conventional model selection approaches, the new approach constructs a separation penalty with multidirectional shrinkages, which facilitates individualized modeling to distinguish strong signals from noisy ones and selects different relevant variables for different individuals.…

随机效应分布未指定时混合效应模型的条件推断函数AI 解读

In longitudinal studies, mixed-effects models are important for addressing subject-specific effects. However, most existing approaches assume a normal distribution for the random effects, and this could affect the bias and efficiency of the fixed-effects estimator. Even in cases where the estimation of the fixed effects is robust with a misspecified distribution of the random effects, the estimation of the random effects could be invalid. We propose a new approach to…

纵向数据相关结构的信息性估计与选择AI 解读

Identifying an informative correlation structure is important in improving estimation efficiency for longitudinal data. We approximate the empirical estimator of the correlation matrix by groups of known basis matrices that represent different correlation structures, and transform the correlation structure selection problem to a covariate selection problem. To address both the complexity and the informativeness of the correlation matrix, we minimize an objective function…

估计方程框架下纵向数据的一致模型选择与数据驱动光滑检验AI 解读

Summary Model selection for marginal regression analysis of longitudinal data is challenging owing to the presence of correlation and the difficulty of specifying the full likelihood, particularly for correlated categorical data. The paper introduces a novel Bayesian information criterion type model selection procedure based on the quadratic inference function, which does not require the full likelihood or quasi-likelihood. With probability approaching 1, the criterion…

纵向数据中次序约束假设的检验AI 解读

Summary In many biomedical studies, we are interested in comparing treatment effects with an inherent ordering. We propose a quadratic score test (QST) based on a quadratic inference function for detecting an order in treatment effects for correlated data. The quadratic inference function is similar to the negative of a log-likelihood, and it provides test statistics in the spirit of a χ2-test for testing nested hypotheses as well as for assessing the goodness of fit of…