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Representation Retrieval Learning for Heterogeneous Data Integration

异质数据整合的表征检索学习

In the era of big data, large-scale, multi-source, multi-modality datasets are increasingly ubiquitous, offering unprecedented opportunities for predictive modeling and scientific discovery. However, these datasets often exhibit complex heterogeneity, such as covariates shift, posterior drift, and blockwise missingness, which worsen predictive performance of existing supervised learning algorithms. To address these challenges simultaneously, we propose a novel Representation…

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Individualized Dynamic Mediation Analysis Using Latent Factor Models

基于潜在因子模型的个体化动态中介分析

Mediation analysis plays a crucial role in causal inference as it can investigate the pathways through which treatment influences outcome. Most existing mediation analysis assumes that mediation effects are static and homogeneous within populations. However, mediation effects usually change over time and exhibit significant heterogeneity among individuals in many real-world applications. Additionally, the mediation mechanism can be complicated and involves non-sparse, making…

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Covariate-Elaborated Robust Partial Information Transfer with Conditional Spike-and-Slab Prior

基于条件尖峰—厚尾先验的协变量细化稳健部分信息迁移

The popularity of transfer learning stems from the fact that it can borrow information from useful auxiliary datasets. Existing statistical transfer learning methods usually adopt a global similarity measure between the source data and the target data, which may lead to inefficiency when only partial information is shared. In this paper, we propose a novel Bayesian transfer learning method named “CONCERT” to allow robust partial information transfer for high-dimensional data…

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Local Signal Detection on Irregular Domains with Generalized Varying Coefficient Models

利用广义变系数模型检测不规则区域中的局部信号

In spatial analysis, it is essential to understand and quantify spatial or temporal heterogeneity. This paper focuses on the generalized spatially varying coefficient model (GSVCM), a powerful framework to accommodate spatial heterogeneity by allowing regression coefficients to vary in a given spatial domain. We propose a penalized bivariate spline method for detecting local signals in GSVCM. The key idea is to use bivariate splines defined on triangulation to approximate…

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Reinforcement learning for individual optimal policy from heterogeneous data

利用异质数据学习个体最优策略的强化学习

Offline reinforcement learning (RL) aims to find optimal policies in dynamic environments in order to maximize the expected total rewards by leveraging pre-collected data. Learning from heterogeneous data is one of the fundamental challenges in offline RL. Traditional methods focus on learning an optimal policy for all individuals with pre-collected data from a single episode or homogeneous batch episodes, and thus, may result in a suboptimal policy for a heterogeneous…

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Optimal Transport based Cross-Domain Integration for Heterogeneous Data

基于最优传输的异质数据跨域整合

Detecting dynamic patterns shared across heterogeneous datasets is a critical yet challenging task in many scientific domains, particularly within the biomedical sciences. Systematic heterogeneity inherent in diverse data sources can significantly hinder the effectiveness of existing machine learning methods in uncovering shared underlying dynamics. Additionally, practical and technical constraints in real-world experimental designs often limit data collection to only a…

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A Model-Agnostic Graph Neural Network for Integrating Local and Global Information

整合局部与全局信息的模型无关图神经网络

Graph Neural Networks (GNNs) have achieved promising performance in a variety of graph-focused tasks. Despite their success, however, existing GNNs suffer from two significant limitations: a lack of interpretability in their results due to their black-box nature, and an inability to learn representations of varying orders. To tackle these issues, we propose a novel Model-agnostic Graph Neural Network (MaGNet) framework, which is able to effectively integrate information of…

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Optimal individualized treatment rule for combination treatments under budget constraints

预算约束下组合治疗的最优个体化治疗规则

Abstract The individualized treatment rule (ITR), which recommends an optimal treatment based on individual characteristics, has drawn considerable interest from many areas such as precision medicine, personalized education, and personalized marketing. Existing ITR estimation methods mainly adopt 1 of 2 or more treatments. However, a combination of multiple treatments could be more powerful in various areas. In this paper, we propose a novel double encoder model (DEM) to…

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De-confounding Causal Inference Using Latent Multiple-Mediator Pathways

利用潜在多中介路径消除因果推断中的混杂

Causal effect estimation from observational data is one of the essential problems in causal inference. However, most estimation methods rely on the strong assumption that all confounders are observed, which is impractical and untestable in the real world. We develop a mediation analysis framework inferring the latent confounder for debiasing both direct and indirect causal effects. Specifically, we introduce generalized structural equation modeling that incorporates…

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Crowdsourcing Utilizing Subgroup Structure of Latent Factor Modeling

利用潜在因子模型子群结构的众包标注

Crowdsourcing has emerged as an alternative solution for collecting large scale labels. However, the majority of recruited workers are not domain experts, so their contributed labels could be noisy. In this paper, we propose a two-stage model to predict the true labels for multicategory classification tasks in crowdsourcing. In the first stage, we fit the observed labels with a latent factor model and incorporate subgroup structures for both tasks and workers through a…

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Estimating Optimal Infinite Horizon Dynamic Treatment Regimes via pT-Learning

通过 pT-Learning 估计无限期最优动态治疗方案

Recent advances in mobile health (mHealth) technology provide an effective way to monitor individuals’ health statuses and deliver just-in-time personalized interventions. However, the practical use of mHealth technology raises unique challenges to existing methodologies on learning an optimal dynamic treatment regime. Many mHealth applications involve decision-making with large numbers of intervention options and under an infinite time horizon setting where the number of…

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High-Order Joint Embedding for Multi-Level Link Prediction

面向多层次连边预测的高阶联合嵌入

Link prediction infers potential links from observed networks, and is one of the essential problems in network analyses. In contrast to traditional graph representation modeling which only predicts two-way pairwise relations, we propose a novel tensor-based joint network embedding approach on simultaneously encoding pairwise links and hyperlinks onto a latent space, which captures the dependency between pairwise and multi-way links in inferring potential unobserved…

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Correlation Tensor Decomposition and Its Application in Spatial Imaging Data

相关张量分解及其在空间影像数据中的应用

Multi-dimensional tensor data have gained increasing attention in the recent years, especially in biomedical imaging analyses. However, the most existing tensor models are only based on the mean information of imaging pixels. Motivated by multimodal optical imaging data in a breast cancer study, we develop a new tensor learning approach to use pixel-wise correlation information, which is represented through the higher order correlation tensor. We proposed a novel…

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Multicategory Angle-Based Learning for Estimating Optimal Dynamic Treatment Regimes With Censored Data

利用多类别角度学习估计删失数据下的最优动态治疗方案

An optimal dynamic treatment regime (DTR) consists of a sequence of decision rules in maximizing long-term benefits, which is applicable for chronic diseases such as HIV infection or cancer. In this article, we develop a novel angle-based approach to search the optimal DTR under a multicategory treatment framework for survival data. The proposed method targets to maximize the conditional survival function of patients following a DTR. In contrast to most existing approaches…

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Topic Modeling on Triage Notes With Semiorthogonal Nonnegative Matrix Factorization

利用半正交非负矩阵分解对分诊记录进行主题建模

Emergency department (ED) crowding is a universal health issue that affects the efficiency of hospital management and patient care quality. ED crowding frequently occurs when a request for a ward-bed for a patient is delayed until a doctor makes an admission decision. In this case study, we build a classifier to predict the disposition of patients using manually typed nurse notes collected during triage as provided by the Alberta Medical Center. These predictions can…

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Integrating Multisource Block-Wise Missing Data in Model Selection

模型选择中多来源分块缺失数据的整合

For multisource data, blocks of variable information from certain sources are likely missing. Existing methods for handling missing data do not take structures of block-wise missing data into consideration. In this article, we propose a multiple block-wise imputation (MBI) approach, which incorporates imputations based on both complete and incomplete observations. Specifically, for a given missing pattern group, the imputations in MBI incorporate more samples from groups…

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Community detection with dependent connectivity

连接存在依赖时的社区检测

In network analysis, within-community members are more likely to be connected than between-community members, which is reflected in that the edges within a community are intercorrelated. However, existing probabilistic models for community detection such as the stochastic block model (SBM) are not designed to capture the dependence among edges. In this paper, we propose a new community detection approach to incorporate intra-community dependence of connectivities through the…

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Individualized Multidirectional Variable Selection

个体化多方向变量选择

In this article, we propose a heterogeneous modeling framework which achieves individual-wise feature selection and heterogeneous covariates’ effects subgrouping simultaneously. In contrast to conventional model selection approaches, the new approach constructs a separation penalty with multidirectional shrinkages, which facilitates individualized modeling to distinguish strong signals from noisy ones and selects different relevant variables for different individuals.…

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Scalable Collaborative Ranking for Personalized Prediction

面向个性化预测的可扩展协同排序

Ben Daiab, Xiaotong Shena, Junhui Wangb & Annie Quc* a School of Statistics, University of Minnesota , Minneapolis , MN ; b School of Data Science, City University of Hong Kong , Kowloon Tong, Hong Kong ; c Department of Statistics, University of Illinois at Urbana Champaign , Champaign , IL Supplementary materials for this article are available online. Please go to www.tandfonline.com/r/JASA. CONTACT Annie Qu anniequ@illinois.edu Department of Statistics, University of…

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Individualized Multilayer Tensor Learning With an Application in Imaging Analysis

个体化多层张量学习及其影像分析应用

This work is motivated by multimodality breast cancer imaging data, which is quite challenging in that the signals of discrete tumor-associated microvesicles are randomly distributed with heterogeneous patterns. This imposes a significant challenge for conventional imaging regression and dimension reduction models assuming a homogeneous feature structure. We develop an innovative multilayer tensor learning method to incorporate heterogeneity to a higher-order tensor…

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Multilayer tensor factorization with applications to recommender systems

多层张量分解及其在推荐系统中的应用

Recommender systems have been widely adopted by electronic commerce and entertainment industries for individualized prediction and recommendation, which benefit consumers and improve business intelligence. In this article, we propose an innovative method, namely the recommendation engine of multilayers (REM), for tensor recommender systems. The proposed method utilizes the structure of a tensor response to integrate information from multiple modes, and creates an additional…

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A Group-Specific Recommender System

群组特定的推荐系统

In recent years, there has been a growing demand to develop efficient recommender systems which track users’ preferences and recommend potential items of interest to users. In this article, we propose a group-specific method to use dependency information from users and items which share similar characteristics under the singular value decomposition framework. The new approach is effective for the “cold-start” problem, where, in the testing set, majority responses are…

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Weak signal identification and inference in penalized model selection

惩罚模型选择中的弱信号识别与推断

Weak signal identification and inference are very important in the area of penalized model selection, yet they are underdeveloped and not well studied. Existing inference procedures for penalized estimators are mainly focused on strong signals. In this paper, we propose an identification procedure for weak signals in finite samples, and provide a transition phase in-between noise and strong signal strengths. We also introduce a new two-step inferential method to construct…

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Estimation and model selection in generalized additive partial linear models for correlated data with diverging number of covariates

协变量维数增长时相关数据的广义可加部分线性模型估计与选择

We propose generalized additive partial linear models for complex data which allow one to capture nonlinear patterns of some covariates, in the presence of linear components. The proposed method improves estimation efficiency and increases statistical power for correlated data through incorporating the correlation information. A unique feature of the proposed method is its capability of handling model selection in cases where it is difficult to specify the likelihood…

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