A Model for Evaluating Sensitivity and Specificity for Correlated Diagnostic Tests in Efficacy Studies with an Imperfect Reference Test
不完美参照检验下相关诊断检验的灵敏度与特异度评估
The purpose of a diagnostic efficacy study is to evaluate and compare the sensitivities and specificities of several diagnostic tests. Usually the diagnostic tests are correlated conditional on disease status, and the reference test is subject to error. In the Chlamydia trachomatis study, five screening tests for detecting chlamydia in endocervical specimens were compared. The five tests are correlated, and the reference test (the cell culture test) has less than 100%…