Multi-objective optimal designs in comparative clinical trials with covariates: The reinforced doubly adaptive biased coin design
含协变量临床试验的多目标最优设计：强化双重自适应偏币设计
The present paper deals with the problem of allocating patients to two competing treatments in the presence of covariates or prognostic factors in order to achieve a good trade-off among ethical concerns, inferential precision and randomness in the treatment allocations. In particular we suggest a multipurpose design methodology that combines efficiency and ethical gain when the linear homoscedastic model with both treatment/covariate interactions and interactions among…