Supremum weighted log-rank test and sample size for comparing two-stage adaptive treatment strategies
比较两阶段自适应治疗策略的上确界加权对数秩检验与样本量
In two-stage adaptive treatment strategies, patients receive an induction treatment followed by a maintenance therapy, given that the patient responded to the induction treatment they received. To test for a difference in the effects of different induction and maintenance treatment combinations, a modified supremum weighted log-rank test is proposed. The test is applied to a dataset from a two-stage randomized trial and the results are compared to those obtained using a…