The covariate-adaptive biased coin design for balancing clinical trials in the presence of prognostic factors
含预后因素临床试验的协变量自适应偏币设计
The present paper deals with sequential designs intended to balance the allocations of two competing treatments in the presence of prognostic factors. After giving a theoretical framework on the optimality of balanced designs that can arise when covariates are taken into account, we propose a new family of covariate-adaptive randomized designs that represents higher order approximation to balance treatments, both globally and also across covariates. We derive the theoretical…